nk3 receptor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7549	Talnetant	SB 223412	Neurokinin receptor
	Talnetant (SB 223412) is a selective, competitive, brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic neurotransmission		Neurokinin receptor
T7633	Senktide		Neurokinin receptor
	Senktide is an agonist of tachykinin NK3 receptor.		Neurokinin receptor
TP1851L	Scyliorhinin II acetate		Neurokinin receptor
	Scyliorhinin II acetate is a selective agonist of the neurokinin-3 (NK3) receptor (Ki = 2.5 nM) in rat cerebral cortex.		Neurokinin receptor
T16114	Pavinetant	AZD4901,MLE-4901,AZD2624	MEK
	Pavinetant is a small molecule orally active and selective neurokinin-3 (NK3) receptor antagonist for the treatment of hot flashes and polycystic ovarian syndrome (PCOS), which is a potential compound for the treatment o...		MEK
TP1899L1	Hemokinin 1 (human) acetate(491851-53-7 free base)		Neurokinin receptor
	Hemokinin 1 (human) acetate is an endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has prolifera...		Neurokinin receptor
TP1851	Scyliorhinin II
	Scyliorhinin II, a cyclic Tachykinin peptide, is a potent NK3 receptor agonist.
T23395	SSR 146977 hydrochloride		Others
	NK3 receptor antagonist		Others
T16408	Osanetant	SR142801	Others
	Osanetant produces anxiolytic- and antidepressant-like effects. Osanetant is a selective NK3 receptor antagonist. It is researched for schizophrenia.		Others
T32004	GSK172981	GSK 172981,GSK-172981
	GSK172981 is a non-peptide tachykinin NK3 receptor antagonist with a high affinity for the recombinant human (PK (I) value 7.7) and native guinea pig (PK (I) value 7.8) tachykinin NK3 receptor. In vitro, the functional e...
T68623	RO4583298
	RO4583298 is a highly potent dual NK1/NK3 receptor antagonist with in vivo activity.
T10892	CS-003 Free base		Neurokinin receptor
	CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3 nM and 0.54 nM, respectively And 0.74 nM. CS-003 free base ...		Neurokinin receptor
T62199	Talnetant hydrochloride
	Talnetant (SB 223412) hydrochloride is a selective NK3 receptor antagonist that acts in hNK-3-CHO cells (Ki: 1.4 nM). Talnetant hydrochloride is 100 times more selective for the hNK-3 receptor than the hNK-2 receptor and...
T78104	Fosnetupitant chloride monohydrochloride	Pronetupitant chloride monohydrochloride	Neurokinin receptor
	Fosnetupitant chloride monohydrochloride (Pro-netupitant chloride monohydrochloride) is a selective NK1 antagonist exhibiting high affinity for the human NK1 receptor with a pK i value of 9.5, and a lower affinity for th...		Neurokinin receptor
T7633L	Senktide acetate	Senktide acetate(106128-89-6 free base)	Neurokinin receptor
	Senktide acetate (Senktide acetate(106128-89-6 free base)) is a selective tachykinin NK3 receptor agonist that promotes the consolidation or expression of ELM for the study of Alzheimer's disease.		Neurokinin receptor
T75840	Hemokinin 1, human TFA
	Hemokinin 1, human TFA acts as a selective full agonist at the tachykinin neurokinin 1 (NK1) receptor, while also being a full agonist at NK2 and NK3 receptors. It is capable of inducing opioid-independent analgesia [1] ...
TP2023	GR 64349
	Potent and selective tachykinin NK2 receptor agonist (EC50 = 3.7 nM in rat colon). Displays > 1000- and > 300-fold selectivity over NK1 and NK3 receptors respectively. Active in vivo.
T74413	(S)-Osanetant
	(S)-Osanetant, the S-enantiomer of Osanetant (SR142801), is a selective NK3 receptor antagonist known for its anxiolytic- and antidepressant-like effects. It is currently under investigation for potential use in treating...
T75881	GR 64349 TFA
	GR 64349 is a potent and highly selective NK2 receptor peptide antagonist, demonstrating an EC50 of 3.7 nM in rat colon. It exhibits over 1000-fold selectivity against NK1 receptors and over 300-fold selectivity against ...
TP1899	Hemokinin 1, human	Hemokinin 1 (human)
	Endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on ...
T70456	Nolpitantium Free Base
	Nolpitantium Free Base is a highly selective nonpeptide antagonist of neurokinin-1 (NK1) receptor. Nolpitantium potently, selectively and competitively inhibited substance P binding to NK1 receptors from various animal s...